About Prempro (generic):

Common Uses: This medicine is a combination of hormones (estrogen and progestin) used to treat menopausal symptoms (e.g., hot flashes, vaginal dryness). It is also used to prevent bone loss (osteoporosis) in people at high risk. If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. There are several medicines (e.g. raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen/progestin HRT for osteoporosis. If you have other medical conditions as well and are prescribed estrogen/progestin HRT for more than one condition, consult your doctor about your treatment plan and its options.

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Additional Information:

Generic Name: E: CONJUGATED ESTROGENS (ESS-troe-jenz) and MEDROXYPROGESTERONE (me-DROX-ee-proe-JESS-te-rone)

How to use this Medicine: Follow the directions for using this medicine provided by your doctor. THIS MEDICINE COMES with a patient information leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have before using this medicine. This medicine is usually taken once daily. This medicine may be taken with food or immediately after a meal to prevent stomach upset. TRY TO TAKE THIS MEDICINE at the same time every day. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C), away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.

Cautions: KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. You should have a complete physical examination, including blood pressure measurements, breast and pelvic examinations, and a PAP test (for vaginal cancer), at least once a year. You should also have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately. DO NOT INCREASE YOUR DOSE, take this medicine more often than prescribed, or stop taking this medicine without checking with your doctor. BEFORE YOU HAVE SURGERY, or will be confined to a chair or bed for a long period of time (e.g., a long plane flight), tell the doctor that you are using this medicine. Special precautions may need to be taken in these circumstances while you are taking this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure your doctors and laboratory personnel know you are using this medicine. THIS MEDICINE MAY CAUSE DIZZINESS. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Limit alcoholic beverages. THIS MEDICINE MAY CAUSE dark skin patches on your face (melasma). Exposure to the sun may make these patches darker. If patches develop, consult your doctor about the use of sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths. SMOKING WHILE USING THIS MEDICINE may increase your risk of blood clots (especially in women over the age of 35). DO NOT USE THIS MEDICINE if you are pregnant. IF YOU SUSPECT THAT YOU COULD BE PREGNANT, contact your doctor immediately. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while using this medicine.

Possible Side Effects: SIDE EFFECTS that may go away during treatment, include dizziness, lightheadedness, headache, stomach upset, bloating, irritability, changes in sleep patterns, fatigue, nausea, weight changes, increased or decreased interest in sex, or breast tenderness. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR IMMEDIATELY if you experience mental or mood changes (e.g., severe depression, memory loss); calf pain or swelling; sudden severe headache; chest pain; trouble breathing; one-sided weakness; slurred speech; vision changes (e.g., change in contact lens fit, loss of vision); breast lumps; swelling of hands and feet; changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, or prolonged bleeding); unusual vaginal discharge, itching, or odor; or yellowing of eyes or skin. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Prempro (generic)

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Dosage and amounts subject to availability:
.625/2.5 mg 100 tablets

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FDA Warns on Black-Market IUDs : WASHINGTON -- Many intrauterine devices (IUDs) sold over the Internet from foreign pharmacies are not approved in the U.S. and are possibly dangerous, the FDA said. The agency said an investigation disclosed that patients in Rhode Island, Massachusetts, and Kentucky had received unapproved IUDs from healthcare providers who had bought them from foreign pharmacies, presumably to save money. In a "Dear Colleague" letter to providers, the FDA said it had uncovered distribution of "unapproved versions of FDA-approved products such as Mirena, Implanon, Copper-T, and ParaGard; as well as products not approved for use in the U.S., such as T-Safe." These products may not be as effective or safe as FDA-approved IUDs, the agency warned. Women who believe they may have received an unapproved IUD should use another contraceptive method and talk to their healthcare providers, the FDA recommended. The FDA also advised physicians to use extra caution when asked to insert IUDs provided by patients. Healthcare providers should verify that products are authentic FDA-approved devices and were purchased from a licensed U.S.-based supplier. The agency also noted that billing Medicaid or private insurers for unapproved medical products could bring criminal fraud charges. "To reduce the chance of receiving an unapproved or adulterated medical product, your Internet purchases should be made from state-licensed distributors or pharmacies located in the U.S.," the FDA said. It recommended buying only from Internet pharmacies displaying a logo from the National Association of Boards of Pharmacy, known as the VIPPS seal for Verified Internet Pharmacy Practice Sites. "Healthcare providers should be aware that purchasing medical products from websites that are outside of the U.S. may be illegal and may increase the risk of receiving a potentially harmful product, since many websites sell products that are not FDA approved and could be manufactured in other countries." The FDA first became aware of the problem in Rhode Island, but its probe turned up unapproved products in the two other states. The investigation is continuing, the agency said.

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